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Genes Dev 2014
Walling (2018) Radical
This triggers intrinsic tyrosine kinase activity
In experimental models, suppression of spermatogenesis in the testes and degeneration of primordial follicles and granulosa cells in the ovaries are considered hallmark features of platinum-induced gonadotoxicity.8 Chemotherapeutic agents have been shown to deplete intracellular Glutathione (GSH), one of the major endogenous antioxidants, while simultaneously increasing Myeloperoxidase (MPO) activity, an indicator of inflammatory response, and elevating Malondialdehyde (MDA), a marker of lipid peroxidation.9 Co-administration of antioxidants during chemotherapy has therefore been proposed as a strategy to mitigate oxidative stress-induced tissue injury and improve therapeutic tolerance
These endocrine-disrupting chemicals are most often found in the plastics used in water bottles, containers, and food packaging, pesticides used on non-organic produce, and phthalates used in many personal care products like shampoos, deodorants, cosmetics, tampons, and more
