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But what drives this persistent exhaustion

Unfortunately, this conventional clinical strategy sheds little light on the underlying infertility etiology or the functional integrity of a patients spermatozoa and has thus proven to be of limited utility in predicting fertilization success ( via the coupling of ultra-high magnification with machine learning [i.e., motile sperm organelle morphology examination (MSOME)], with the goal of standardizing the detection of morphological anomalies, it remains uncertain which elements of sperm structure define the functionality of this highly specialized cell

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Volkert D, Chourdakis M, Faxen-Irving G, Fruhwald T, Landi F, Suominen MH, et al