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Regarding comorbidities, chronic kidney disease was present in 17.4% of both cohorts, and obstructive sleep apnea occurred in 26.6% of the GLP-1 RA group and 26.7% of the control group

Dual GIP/GLP-1 agonists may be better for patients who havent achieved sufficient weight loss with GLP-1 medications alone, those requiring more aggressive metabolic intervention, individuals who can tolerate the slightly higher side effect rates at maximum doses, and patients seeking the most effective currently available FDA-approved option

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FDA-approved medications undergo years of clinical trials before they ever reach a patient

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