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Semen analysis in sickle cell disease
Front Cell Dev Biol
Iron accumulation further amplifies ROS generation through the Fenton reaction, and triggers ferroptosis through lipid peroxidation and GSH depletion in activated HSCs, thereby providing a brake on the fibrogenic response (65)
By comparison, the rate constant for thiol oxidation by superoxide (O 2 ) has been estimated to be in the range of 100 M 1 s 1 ( 2 -concentration is restricted by superoxide dismutase to approximately 10 10 M ( in vitro to O 2 -that was steadily produced by xanthine oxidase (2 M/min over a period of 4 h)
Ethics declarations Competing interests The authors declare no competing interests
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