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In addition to dampening NF-B activity, KPV has been shown to downregulate the expression of adhesion molecules on endothelial and immune cells, limiting the recruitment and infiltration of leukocytes into inflamed tissues.(7) This targeted modulation extends to the suppression of pro-inflammatory cytokines such as interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-), thereby mitigating excessive inflammatory cascades without broadly compromising host immune competence (8)

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Proc Natl Acad Sci USA 100:91969201 Mohr S, Stamler JS, Brune B (1994) Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents