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Any symptom relief is likely due to weight loss and lower general inflammation, not a targeted effect on endometriotic tissue

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The recurring interplay of oxidative stress, inflammatory activation, and disrupted cellular signalling provides a unifying mechanistic framework linking renal, musculoskeletal, cutaneous, immunological, respiratory, gastrointestinal, and reproductive dysfunctions to those already described in cardiovascular, hepatic, and gonadal tissues ( Taken together, the current body of evidence suggests that supraphysiological androgen exposure disrupts endocrine regulation at multiple levelsfrom hypothalamic control to testicular cellular architecturethrough oxidative, mitochondrial, and epigenetic mechanisms ( To facilitate synthesis of the extensive narrative data presented in Sections 6 and 7, a summary table is provided below, integrating the major psychological and physical adverse effects associated with non-medical testosterone and anabolicandrogenic steroid use across organ systems ( Table 2 )

The FDA Label Warning The FDA-approved prescribing information for isotretinoin states directly: "Isotretinoin may cause depression, psychosis, and, rarely, suicidal ideation, suicide attempts, suicide, and aggressive and/or violent behaviors." The full prescribing information is available via FDA accessdata