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Retatrutide appears to produce the fastest weight loss trajectory, with participants in Phase 2 trials losing 24.2% of body weight in just 48 weeks, a pace that outstrips semaglutide and tirzepatide over comparable timeframes

Treatment with GLP-1 and exendin-4 significantly increased neurite length in cultured DRG neurons, potentially accounting for the increased nerve fibers observed in IBS biopsies [55] (Fig

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