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Huemer, M., Shambat, S

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Tumor suppression in humans relies on the immune system, but metastatic tumor cells can evade immune detection by using checkpoints like CTLA-4 and PD-1/PD-L1, thereby inhibiting immune responses and weakening anticancer immunity.This version simplifies and streamlines the information for better readability and clarity ( + tumor-infiltrating T cells enhance the expression of PD-1 and CTLA-4 in patients with pancreatic ductal adenocarcinoma (PDAC) (Wartenberg et al., 2018)

To address this, we used updated voxelwise methods and retrospectively analyzed a [ 11 C]raclopride-PET dataset to measure D 2/3 receptor availability and relative cerebral blood flow (R1) in male opioid use disorder (OUD) participants ( n = 10) during placebo and acute opioid withdrawal conditions