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Anyone suspecting B12 deficiency especially with neurological symptoms should seek GP review promptly rather than self-treating with over-the-counter supplements

Peer-reviewed case reports document serious adverse events attributed to unsupervised, non-research self-administration of melanotan analogs, including melanoma cases reported in association with concurrent ultraviolet exposure (Hjuler & Lorentzen, Dermatology 228:346, 2014, PMID 24355990

In January, a paper in JAMA Ophthalmology reported nine cases of people who experienced eye problems while taking GLP-1 drugs - six on semaglutide and three on tirzepatide

expounded on the obesity paradox, suggesting increased BMD is offset by poor bone quality due to advanced glycation end-products (AGEs) accumulation, impaired osteoblast function, and uncoupled bone turnover favoring resorption

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