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Decreased vitamin B12 absorption due to altered gut microbiota Potential for megaloblastic anemia in prolonged use Increased risk of neuropathy and other neurological complications Dose and Duration Considerations The risk of B12 deficiency with metformin depends on the dose and how long you take it

2009 Jul-Sep;21(3):92-4

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Therefore, it is crucial to inform your healthcare provider of all medications, supplements, and vitamins that you are taking before starting this medication