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The KEGG enrichment terms analysis revealed that purine metabolism and pentose phosphate pathway (PPP) are the most affected metabolic pathways with Cr GPDH expression ( Figure 3b )

Further studies revealed that salidroside, an antioxidant with antioxidant properties, significantly attenuated oxidative stress-mediated retinal damage by activating the nuclear factor Nrf2/SLC7A11/GPX4 signaling axis

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3,26 Cirrhosis does not occur in these patients

Nunes-Souza V, Csar-Gomes CJ, Da Fonseca LJ, Guedes Gda S, Smaniotto S, Rabelo LA (2016) Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL/6 mice: improvement in glycemic and lipid profile after antioxidant therapy