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Lancet 399:14121428

K.RenaudJ.KagaleS.DhaubhadelS

For xenobiotic treatment, cultures in mold and yeast phases were grown for 72 h, and 0.02 mM 1-chloro-2,4-dinitrobenzene (CDNB) (Sigma-Aldrich, City, Country) was added for 1 h with continuous shaking at 200 rpm

This suggests that the higher rates of glucuronidation associated with this UGT1 polymorphism protect against paracetamol hepatotoxicity by decreasing the fractional proportion of paracetamol available for oxidation