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Twice-daily dosing is used in some early-phase research protocols to maintain more consistent receptor activation during the initial neuroplasticity induction period, but this approach increases total daily exposure and may elevate the risk of off-target effects

PT-141 concentrates its activity at MC3R and MC4R in the paraventricular nucleus of the hypothalamus

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Independently of its antioxidant function, the compound has an anti-inflammatory role too, reducing the production of interleukines and the expression of TNF-alfa and iNOS synthase

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