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Gastrointestinal effects Nausea, the most common side effect, tends to reappear during dose escalation periods

It affects a significant majority of people starting GLP-1 treatment, with studies showing that 40 to 50 percent of patients experience nausea, particularly during dose escalation

Worsened gastrointestinal side effects Like other GLP-1 medications , semaglutide slows gastric emptying (i.e

Most patients report meaningful appetite suppression within the first two weeks, though the exact timing varies based on individual metabolism, starting dose, and genetic factors affecting GLP-1 receptor sensitivity

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