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Importantly, their glucose-dependent mechanism means insulin secretion only occurs when blood glucose levels are elevated, substantially reducing hypoglycaemia risk

At the N-terminus sites of proteins 5-oxoproline contributes to both function and stability (Cummins and OConnor, 1998)

Notably, they provide testosterone therapy for men, which might be a relevant consideration for some individuals seeking both weight management and hormone therapy

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doi: 10.1038/s41573-021-00154-z 134 DuGHealyLBDavidLWalkerCEl-BabaTJLutomskiCAet al