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Methylene Blue A heterocyclic aromatic compound known for its redox activity and mitochondrial interactions in laboratory studies

B-12, or cobalamin, is a vitamin essential for the proper functioning of the nervous system

Conceptualization, YH and LM

Glucose-dependent insulinotropic peptide (GIP), which has been described as an incretin hormone in some mammals (e.g., human ( Homo sapiens ) and mouse ( Mus musculus )) (23), is encoded by the Gip gene and is found in most vertebrates (24, 25)

Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells