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These factors might not fully elucidate the direct causal relationship between YTHDF1 and the observed downstream effects with absolute precision

3.2 MTHFD2 MTHFD2, traditionally recognized for its enzymatic roles in folate metabolism, has recently emerged as a multifaceted regulator with crucial non-enzymatic functions, including the regulation of DNA damage repair, cell cycle progression, RNA metabolism, and RNA methylation (Fig