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Lahiri, Indiana UniversityPurdue University Indianapolis, United States

The copper ion is essential for its biological activity, as it enables the peptide to serve as a bioavailable copper delivery system

As toxicologic pathologists sometimes experience difficulties in distinguishing the wide variety of liver lesions in the rodents for safety evaluation purposes, this document is a consensus of senior toxicologic pathologists regarding suggested nomenclature that should be used for specific lesions

Thus, B2M-CuS NPs can effectively treat OA by clearing senescent chondrocytes and promoting cartilage regeneration after intra-articular injection into the knee joints of surgery-induced OA mice