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Lancet 375:14471456 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects

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[8] With patches there is no such data

HuhY-JKimJ-MKimHSongHSoHLeeSYet alRegulation of osteoclast differentiation by the redox-dependent modulation of nuclear import of transcription factors

But they appear to have a higher risk of bone fractures and a recent study suggested an increase risk of haemorrhagic stroke