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Higher exposure can produce greater weight loss, as trials including a 7.2 mg regimen and reports of tripling standard doses showed larger reductions than smaller doses or placebo, but those gains come with clear tolerability and safety trade-offs

A 2019 study into people who regularly consume pre-workout found that 54% of participants reported side effects, including nausea, skin reactions, and heart abnormalities

These products are often not uniformly manufactured or quality tested, and regulation of their production and sale can be limited, requiring consumer awareness

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