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Anecdotal reports suggest that roughly 10-15% of semaglutide users experience some form of skin-related change, ranging from mild dryness to more pronounced inflammation

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Moreover, postmortem analyses of brain structures from individuals who died by suicide showed astrocytic irregularities, including reduced levels of GFAP mRNA and protein in mood-regulating regions like the medial thalamus and caudate nucleus

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Some practitioners extend treatment to 6 months, though this remains controversial