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Notably, oxidative stress has a dual role in exercise physiologywhile excessive levels can impair performance, moderate levels are essential for physiological adaptation 64,65

The FDA nod, which the companies announced on Friday, is specifically for the reduction of risk of sustained decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease and cardiovascular death and hospitalization in adults with CKD at risk of progression

doi: 10.1186/1471-2474-12-153

Furthermore, the anti-oxidative stress effector heme oxygenase 1 (HO-1) was also upregulated (Fig