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This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism

This means you might not be getting the "master antioxidant" benefits you expect

However, some gastrointestinal side effects have also been observed during BBR treatment

E., Nakamaru-Ogiso, E., Rabinowitz, J

In contrast, ipamorelins receptor-constrained activity reduces confounding HPA-mediated catabolic signaling