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They often occur during a dose increase as the body adjusts
CAN CAN is one of the most clinically significant forms of DAN due to its strong association with increased morbidity and mortality
The cellular mechanism by which the releasing hormones affect GH secretion from the somatotrope requires specific signal transduction systems (cAMP and/or calcium influx and/or mobilization of intracellular calcium) and/ or tyrosine kinase(s) and/or nitric oxide (NO)/cGMP
doi: 10.1016/j.molcel.2016.04.025 89 LiXLuZDuXYeYZhuJLiYet al
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