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Cortisol elevation is problematic because chronic cortisol excess promotes muscle breakdown, fat storage, immune suppression, and sleep disruption the opposite of what individuals seeking GH optimization want

For example, according to a recent review by researchers in the US looking at peptides often marketed to patients with musculoskeletal injuries, BPC-157 demonstrated potential benefits in tendon and muscle repair, but these findings are largely unvalidated in human trials, with no randomised control trials in humans relating to such uses, and the only case series having serious flaws

In peptide research, margin of error can compromise entire protocols

Removing the physical and emotional discomfort of injections allows patients to focus more on living their lives and less on the mechanics of their treatment

Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010