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The choice of treatment will be based on several factors, including the patient's age, the severity and duration of the symptoms, and preference

Once-weekly dosing is convenient, so patients do take it, but dropout rates globally are 3050%, Dr Mohan said

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The results were impressive, with the highest dose of retatrutide group (12 mg) achieving a mean weight reduction of 17.5% at 24 weeks and a larger reduction of 24.2% at 48 weeks

Growth hormone production begins declining around age 30, with roughly 15% reduction per decade thereafter