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The CNS influences motor, sensory, autonomic and secretory aspects of the gastrointestinal tract, integrates interoceptive information from the gut and returns responses, thus mediating the actions and reactions necessary to support gut and brain health 98

Assists apoptosis (cell death) 7

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To confirm that haem-assisted dimerization of PGRMC1 occurs in solution, we analysed the structure of apo- and haem-bound PGMRC1 by two-dimensional nuclear magnetic resonance (NMR) using heteronuclear single-quantum coherence and transverse relaxation-optimized spectroscopy (Supplementary Figs 6b and 7)