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Researchers screened 70 hypothyroid patients on tirzepatide, ultimately analyzing 17 who met strict criteria, including stable levothyroxine doses before starting tirzepatide and adequate follow-up data

However, it did significantly reduce the decrease in motor nerve conduction velocity and paw intraepidermal fiber density observed in diabetic mice through the activation of extracellular signal-regulated kinase (ERK) signaling [81]

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Different doses in clinical studies contribute directly to the extent to which appetite decreases and weight loss occurs