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Furthermore, fresh mushrooms have a significant moisture content ranging from 85 to 95% and a rapid respiration rate (640.8 mg kg 1 h 1 ) at 10C for Lentinus edodes and (200 to 500 mg kg 1 h 1 ) for Agaricus bisporus which can encourage microbial growth and enzymatic browning, thus accelerating the aging process (38)

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Glutathione can also rapidly break down into amino acid components in plasma, limiting its sustained effectiveness unless administered repeatedly