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Most common are GI: nausea, decreased appetite, constipation, occasional diarrhea, and reflux typically mild to moderate and concentrated during dose escalation

Springer, pp

Andrianu K, Works D, Christiansen A, Enke C, Chaiken L, Baine M

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However, the inhibitory effect of NPW on myeloperoxidase activity and NPW-induced increase in glutathione were not observed in the presence of COX-1 inhibitor ketorolac or the non-selective COX-inhibitor indomethacin