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STEP 1 (Wilding et al., NEJM 2021) enrolled 1,961 adults with overweight or obesity , and explicitly excluded those with diabetes

Subjects then engaged in a moderate 5-week exercise training program twice per week with the final training session on the fifth week of supplementation consisting of a supervised lower-body exercise challenge specifically constructed to induce muscle damage

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In practice, this means Kaiser members are typically prescribed Ozempic at appropriate therapeutic doses for their indication, rather than being transitioned to Wegovy