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Microdosing during titration adds complexity and makes it harder to assess tolerance

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There have been plenty of studies on older, less powerful drugs in the GLP-1 class, such as liraglutide, but semaglutide and tirzepatide represent new territory

About the IMPACT Phase 2b Study The randomized, placebo-controlled, double-blind IMPACT Phase 2b trial ( NCT05989711 ) enrolled 212 participants with biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis stages F2 or F3, with and without diabetes