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To generate sufficient quantities of ROS and RNS quickly, these cells require rapid flux through the PPP to produce sufficient amounts of NADPH to enable superoxide formation from oxygen by the action of NADPH oxidase (NOX), and nitric oxide (NO) formation from arginine by inducible nitric oxide synthase (iNOS) ( Figure 1A-2 )

doi: 10.1158/0008-5472.CAN-05-3796 166

doi:10.1016/j.clnesp.2022.12.019 Llanaj E, Dejanovic GM, Valido E, et al

Stick with the right dose to grab the best results and dodge any nasty side effects

Non-negotiable every morning, indoors or not, with particular attention to the 72 hours after a session