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However, DBS might also increase and regularize the output of the stimulated region by activating local axonsthis is certainly an appealing hypothesis in cerebellar disorders since much of electrophysiological defects could stem from changes in the firing regularity of the cerebellar nuclear neurons

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In the trial, dose escalation occurred every 4 weeks from 0.25 mg at baseline to 2.4 mg at the end of the escalation period