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Deterioration of BBB form and function is a feature part of healthy aging, but it is worsened in many neurodegenerative disorders and is a hallmark of cognitive decline

2021 Dec 26

Responses were amplified using a DAM80 amplifier (World Precision Instruments, Sarasota, FL) using a bandpass from 0.1 Hz to 1 kHz and a Digidata 1440 A (Axon Instruments, San Jose, CA) with a sampling rate of 2 kHz

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HF, a complex clinical syndrome characterized by significant functional impairment and high morbidity, stems from impaired cardiac contractility and/or ventricular filling [199]