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Immune cells use ROS to sustain their functions and need adequate levels of antioxidant defenses to avoid harmful effects caused by excessive ROS production, since accurate balance between ROS and intracellular antioxidants is essential for a normal function of the cell (Banjac et al., 2008

The chemical mechanism: reduced glutathione contains a free thiol group (-SH) on the cysteine residue

Otherwise, supplementation will merely mitigate the damage done

163 As an example, Tiriveedhi et al reported that lung transplant patients, who developed chronic lung allograft rejection, show increased defensin and decreased serum AAT levels along with high concentrations of AAT-defensin complexes in their bronchial lavage

Under normal circumstances, mitochondrial glutathione rapidly neutralizes these byproducts