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This process relies on signaling pathways such as brain-derived neurotrophic factor (BDNF) and NMDA receptor-mediated synaptic plasticity

BMJ 367:1 Tache Y, Perdue M (2004) Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function

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So, its hard to take anything from that other than: thats interesting, we should do a better study. The overwhelming majority of research comes from rodent models, not humans