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About Type 2 Diabetes Type 2 diabetes is a serious condition that affects more than 28 million people in the United States (9.4 percent of the population)

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A large study published in Nature in April 2026 identified specific variants in the GLP1R and GIPR genes that predict differential weight loss and side effect risk on GLP-1 medications

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In the brain, the GHSR 1a is expressed most highly in agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons of the hypothalamus