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Given the conserved chelating properties of transition metal complexes, existing clinical metal chelators can be repurposed and optimized for targeted platinum chelation, with priority given to strategies that reduce platinum accumulation in normal tissues while preserving intratumoral platinum concentrations

Weekly injections of 6 mg resulted in a significant body weight loss of 4.5% after just four weeks of treatment

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As ammonia is not excreted (not water soluble), the remaining 10% is carried on to perivenous hepatocytes where ammonia is condensed with glutamate to glutamine through the glutamine synthetase (GS), a lower capacity system

It also supports cell growth by influencing the production of growth factors like VEGF (vascular endothelial growth factor), essential for tissue regeneration