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Relative expression of the indicated genes was measured with the Applied Biosystems TaqMan Gene Expression Assays with primer/probe sets (Supplementary Table S1), with Glyceraldehyde 3-phosphate dehydrogenase (GADPH) as a reference

Each 2 l aliquot of derivatized sample was injected in 30:1 split ratio into an Agilent 7890B/5977A gas chromatography-mass spectrometry (GC-MS) equipped with HP-5MS capillary column (30 m 0.25 mm 0.25 m, Agilent J & W Scientific, USA)

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