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The inter-organelle complex formed by endosomal GLP-1R, ER VAPB and SPHKAP triggers a pool of ERMCS-localised cAMP/PKA signalling via the formation of a PKA-RI biomolecular condensate which leads to changes in mitochondrial contact site and cristae organising system (MICOS) complex phosphorylation, mitochondrial remodelling, and -cell functional adaptation, with important consequences for the regulation of -cell insulin secretion and survival to stress

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7,8 The mortality rate for those with SLE is high despite early recognition and treatment when compared to the general population