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Typical Post-Injection Timeline First 24-48 hours: Mild to moderate pain at the injection site Localized warmth and redness Slight swelling around the knee Temporary stiffness or reduced range of motion Days 2-3: Gradual reduction in swelling Decreased pain and tenderness Return to normal mobility Possible spongy sensation when walking [4] The American Academy of Orthopaedic Surgeons notes that patients should avoid excessive activity, such as jogging or heavy lifting for the first 48 hours after injection [2]

Recently, we have demonstrated nuclear receptor coactivator 4 (NCOA4) could aggravate OA by promoting chondrocyte ferroptosis and ferritinophagy [123]

However, since these patients are often deficient in vitamin B12, injectable B12 in the form of hydroxycobalamin is often chosen as part of their treatment