Weight loss was similarly amplified: tirzepatide achieved reductions of up to 11.3 kg versus only 2.7 kg with dulaglutide
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Semaglutide works by mimicking GLP-1 (Glucagon-Like Peptide-1), a naturally occurring hormone that: Signals to the brain that you are full, reducing appetite and food cravings Slows gastric emptying, prolonging the feeling of fullness and reducing calorie intake Enhances insulin secretion and improves blood sugar control Decreases glucagon release, preventing unnecessary glucose production By targeting multiple pathways involved in metabolism and appetite regulation, semaglutide makes sustainable weight loss more achievable
Treatment of established hypothyroidism should be with LT4, in preference to other forms of thyroid hormone replacement, with goals of ameliorating symptoms, achieving the euthyroid state and avoiding overtreatment
