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Because occludin, ZO-1, ZO-2, and claudin-5 are phosphoproteins, any changes in phosphorylation may result in altered BBB permeability [88]
Ketorolac works by reducing hormones that cause inflammation and pain in the body
It functions as a cofactor for key enzymatic reactions involved in one-carbon metabolism, nucleic acid synthesis, and mitochondrial energy regulation
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Additionally, fecal metabolism of palmitoleic acid and tryptophan degradation have been linked to the production of TNF- and interferon-gamma (IFN-), both of which are associated with inflammation [37]
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