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High-fat meals, refined carbohydrates, and low-fiber intake may worsen GLP-1-related diarrhea by promoting dysbiosis and reducing short-chain fatty acid production

Phase 2 data: 8.7 percent at 1 mg, 17.1 percent at 4 mg, 22.8 percent at 8 mg, and 24.2 percent at 12 mg over 48 weeks

Strategies such as HDAC inhibition, astrocyte transplantation and modulation of autophagy or metabolic pathways remain confined to experimental models, whereas GLP-1 receptor agonists and MAO-B inhibitors have advanced to clinical testing and show effects on astrocytic metabolism and neuroinflammation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Dahabra L., Broadberry G., Le Gresley A., Najlah M., Khoder M