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Interestingly, a small trial in 30 premenopausal women found that daily multivitamin supplementation for ten weeks did not improve overall mood, but when the supplement also contained 7 mg/day of zinc (RDA=8 mg/day), the authors noted significant improvements in two components of POMS: the anger-hostility and the depression-dejection scores (140)

Journal of Korean Medical Science, 20(5), 721

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These health issues help support the medical justification for prescribing weight loss medication and can change the discussion from being about cosmetic reasons to being about what is medically necessary