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McCarthy DJ, Chen Y, Smyth GK

The mechanism involves glycine exerting a hyperpolarizing effect on macrophages and other immune cells, inhibiting calcium influx through voltage-sensitive channels and thereby dampening their inflammatory activity

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Still, Wong and colleagues concluded that semaglutide could have a significant impact on reducing health care costs associated with obesity and CVD. The ongoing SELECT trial will document the actual impact of semaglutide treatment on cardiovascular outcomes in high-risk adults and established CVD and without diabetes, they wrote.

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