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Pain intensity significantly improved from baseline to month 1 of treatment (pain NRS from 7.4 1.5 to 5.6 1.7)

The connection between GSH, vitamin C and vitamin E is illustrated in Fig

Pediatr Res 52 : 4649 Dani C, Giannini L, Bertini G, Pratesi S, Corsini I, Longini M, Buonocore G, Masini E, Rubaltelli FF 2007 Changes of nitric oxide, carbon monoxide and oxidative stress in term infants at birth

The pathophysiology of AP is strongly influenced by oxidative stress, which results from an imbalance between free radicals and antioxidant defenses, leading to cellular damage

We advise patients with FD to exercise caution when using PPIs and recommend discontinuation of PPI mediation once clinical symptoms are alleviated