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These results were published in February 2025 (Hendershot, Bremmer, Paladino)

One in eight employees would hand back vacation days in exchange for GLP-1 coverage

The most realistic expectation is supportive, gradual change rather than immediate effects

Mechanistically, it makes sense: glutathione is central to toxin clearance, mitochondrial protection, and antioxidant defense, and the nasal route offers a practical way to bypass digestive breakdown and possibly reach brain and respiratory tissues more directly

The delayed gastric emptying caused by semaglutide can increase aspiration risk during anesthesia, so most surgeons recommend discontinuing the medication two to four weeks before scheduled procedures