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Importantly, recent in vivo studies have shown that genetic inhibition of FSP1 alone is sufficient to induce ferroptosis and suppress tumor growth, even in the absence of GPX4 inhibition 80,81

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4e, f, both G/D-CuP and D-CuP exhibited a significant reduction in the expression levels of pro-inflammatory cytokines

243 Furthermore, energy-boosting pathways, including the AMPK and SIRT pathways, enhance FAO and glycolysis, increasing heat generation beyond ATP production under the influence of UCP1

This study had been registered in Chinese Clinical Trial Registry (No